Direct Contacts of K+ Ions in the Selectivity Filter Enable the High Conductance of K+ Channels
نویسندگان
چکیده
منابع مشابه
Preferential binding of K+ ions in the selectivity filter at equilibrium explains high selectivity of K+ channels
K(+) channels exhibit strong selectivity for K(+) ions over Na(+) ions based on electrophysiology experiments that measure ions competing for passage through the channel. During this conduction process, multiple ions interact within the region of the channel called the selectivity filter. Ion selectivity may arise from an equilibrium preference for K(+) ions within the selectivity filter or fro...
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15 صفحه اولExternal TEA Block of Shaker K+ Channels Is Coupled to the Movement of K+ Ions within the Selectivity Filter
Recent molecular dynamic simulations and electrostatic calculations suggested that the external TEA binding site in K+ channels is outside the membrane electric field. However, it has been known for some time that external TEA block of Shaker K+ channels is voltage dependent. To reconcile these two results, we reexamined the voltage dependence of block of Shaker K+ channels by external TEA. We ...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2015
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2014.11.721